Metabolic Syndrome Severity Predicts Mortality in Nonalcoholic Fatty Liver Disease

Background and AimsPrevious studies have examined the effects of metabolic syndrome (MetS) presence rather than severity on mortality risk in nonalcoholic fatty liver disease (NAFLD). We used MetS score, a validated gender- race-specific measure, to assess relationship between NAFLD.MethodsThe study included 10,638 adults aged 20 74 years who participated Third National Health Nutrition Examination Survey. NAFLD was defined as mild, moderate, or severe hepatic steatosis ultrasound without excessive alcohol intake other diseases. Adjusted Cox proportional models were test association score related all-cause, heart disease, diabetes, hypertension.ResultsThe median significantly higher (0.49 [69th] vs −0.23 [41st]). An increase corresponded linear rise biomarkers for cardiovascular insulin resistance, lipid abnormalities, kidney problems. The significant predictor all-cause cause-specific adjusted mortalities. A quartile associated with risks from all-causes hazard ratio (aHR) 1.36 (95% confidence interval [CI]: 1.17–1.57), aHR 1.70 CI: 1.17–2.47), diabetes 3.64 2.27–5.83), hypertension 1.87 1.14–3.04). also nonlinear increased all models.ConclusionThe is clinically accessible tool that can be identify monitor patients at highest mortality. Previous NAFLD. hypertension. models.